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Hyaluronic Acid

Hyaluronic Acid: History, Chemical Structure, and its Benefits for the Body

What is Hyaluronic Acid?

 Hyaluronic Acid (HA), also known as hyaluronan or hyaluronate, is a carbohydrate, more specifically a mucopolysaccharide occurring naturally throughout the human body. It can be several thousands of sugars (carbohydrates) long. When not bound to other molecules, it binds to water giving it a stiff viscous quality similar to “Jello”. This viscous Gel is one of the most heavily researched substances in medicine today with thousands of trials mostly in the fields of orthopedics and eye surgery. Its function in the body is, amongst other things, to bind water and to lubricate movable parts of the body, such as joints and muscles. Its consistency and tissue-friendliness allows it to be beneficial in skin-care products as an excellent moisturizer. Because HA is one of the most hydrophilic (water-loving) molecules in nature with numerous benefits for the human body it can be described as “nature’s moisturizer”.

Hyaluronic Acid Benefits for the Body?

If we compare the joints of the human body to an automobile engine, the joint fluid in the body mimics the oil in a car engine. At regular intervals we replace the oil in our car engines because the heat and friction breakdowns the oils viscosity. The oil becomes thinner and less able to protect the metal surfaces from excessive wear. Hyaluronic acid benefits our joints in the same way. As we age the viscosity of the joint fluid lessens. HA helps to maintain normal joint cushioning.

What is Hyaluronic Acid’s Chemical Structure?HA Hair

It is naturally produced in the human body and is chemically classified as a Glycosaminoglycan. In the body, hyaluronic acid always presents itself as a large high molecular weight molecule. The molecule is made up of a repetitive sequence of two modified simple sugars, one called glucuronic acid and the other N acetyl glucosamine. These compounds are both negatively charged and when put together, they repel producing an exceptionally long stretched out molecule (high molecular weight). HA molecules that are long and large in size produce a high viscosity (lubrication) effect which resists compression and allows our joints and skin to bear weight.

When was Hyaluronic Acid discovered?

HA was first used commercially in 1942 when Endre Balazs applied for a patent to use it as a substitute for egg white in bakery products. Its discovery was very unique. No other molecule had ever been discovered that has such unique properties to the human body. Balazs went on to become the leading expert on HA, and made the majority of discoveries concerning hyaluronic acid benefits.

Where is Hyaluronic Acid located in the body?

Hyaluronic Acid is found naturally in most every cell in the body and occurs in high concentrations in specific body locations. In each body location, it serves a different function. Unfortunately, HA also has a half-life ( the time it takes for the molecule to get broken down and excreted from the body) of less than 3 days and possibly even as little as one day in the skin. For this reason, it is imperative that the body continually replenish itself with HA. Below are some of the areas in the human body where it is present and critical to anatomical function.

Hyaluronic Acid in Bones and CartilageHA Tendons Cartilage

Hyaluronic Acid is found in all bones and cartilage structures throughout the body.  Both of these structures provide a resilient rigidity to the structure of the human body. HA is especially found in various forms of cartilage but none more than the hyaline cartilage. As you’ve probably guessed it, hyaline is short for hyaluronic acid. Hyaline cartilage covers the ends of the long bones where articulation (bending) occurs and provides a cushioning effect for the bones. The hyaline cartilage has been called the “gristle cartilage” because its resistance to wear and tear. Hyaline cartilage also supports the tip of the nose, connects the ribs to the sternum and forms most of the larynx and supporting cartilage of the trachea and bronchial tubes in the lungs.

Hyaluronic Acid in Synovial fluidHA Joint Synovial Fluid

Our joints (like the elbows and knees) are surrounded by a membrane called the synovial membrane which forms a capsule around the ends of the two articulating bones. This membrane secretes a liquid called the synovial fluid. Synovial fluid is a viscous fluid with the consistency of motor oil. It has many functions, but none more than providing the elastic shock absorbing properties of the joint. Its second most important function in the joint is to carry nutrients to the cartilage and to also remove waste from the joint capsule.

Hyaluronic Acid in Tendons and Ligaments/Connective tissue

Connective tissue is found everywhere in the body. It does much more than connect body parts; it has many forms and functions. Its major functions include binding, support, protection, and insulation. One such example of connective tissue is the cordlike structures that connect muscle to bone (tendons) and bone to bone (ligaments). In all connective tissue there are three structural elements. They are ground substance (hyaluronic acid), stretchy fibers (collagen and elastin) and a fundamental cell type. Whereas all other primary tissues in the body are composed mainly of living cells, connective tissues are composed largely of a nonliving ground substance, the hyaluronic acid, which separates and cushions the living cells of the connective tissue. The separation and cushioning allow the tissue to bear weight, withstand great tension and endure abuse that no other body tissue could. All of this is made possible because of the presence of the HA and its ability to form the gelatinous ground substance fluid.

Hyaluronic Acid in Scalp Tissue and Hair FolliclesHA Hair

Structurally the scalp is identical to the skin tissue located throughout the body except it also contains about 100,000 hair follicles that give rise to hair. Actually the hair and the hair follicle are a derivative of skin tissue. There are two distinctive skin layers, one, the epidermis (outer layer) which gives rise to the protective shield of the body and the other, the dermal layer (deep layer) which makes up the bulk of the skin and is where the hair follicle is located. This dermal layer is composed of connective tissue and the connective tissue, with its gelatinous fluid like characteristics provides support, nourishes and hydrates the deep layers of the scalp. The result is healthy lustrous hair and a moisturized scalp. Again, all of this is made possible because of the presence of HA in the scalp.


Hyaluronic Acid in Lips

The lips are a core of skeletal muscle covered by skin tissue. The dermal layer of the lips is composed primarily of connective tissue and its components hyaluronic acid and collagen that give the structure (shape) and plumpness to the lips. The HA binds to water creating a gelatinous fluid that hydrates the surrounding tissue and keeps the collagen (responsible for keeping the skin tight) nourished and healthy. The result is healthy well hydrated and plump lips that are well protected from the environment.

HA eyesHyaluronic Acid in Eyes

Hyaluronic acid is highly concentrated inside the eyeball. The fluid inside the eye called the vitreous humor is composed almost completely of hyaluronic acid. The HA gives the fluid inside the eye a viscous gel like property. This gel acts as a shock absorber for the eye and also serves to transport nutrients into the eye. HA has been directly injected into the eye during procedures to help maintain the shape of the eye during surgery. It has been said that after the 5th decade of life, our eyes stop producing the much needed hyaluronic acid resulting in various eye needs.

 

Hyaluronic Acid in Gum TissueHA teeth

The Gums (gingivoe) are composed of dense fibrous connective tissue (ligaments) which secure the teeth to the aveloar bone (jaw bone). Once again, connective tissue is composed of a fibrous tissue surrounded by hyaluronic acid (extra-cellular matrix). Without the presence of HA, the gum tissue becomes unhealthy. If it is present it helps to provide the tensile strength of the ligaments that secure the tooth in place by providing hydration and nourishment. The result is a healthy set of gums.

Skin Cross Section with HASkin

Although Hyaluronic Acid (HA) can be found naturally in most every cell in the body, it is found in the greatest concentrations in the skin tissue. Almost 50% of the bodies HA is found here. It is found in both the deep underlying dermal areas as well as the visible epidermal top layers. Young skin is smooth and elastic and contains large amounts of HA that helps keep the skin stay young and healthy. The HA provides continuous moisture to the skin by binding up to 1000 times its weight in water. With age, the ability of the skin to produce HA decreases.

ECM (ground substance)HA Ground Substance

The extracellular matrix (ECM) is a gelatinous (gel-like) fluid that surrounds almost all living cells and is essential to life. It gives structure and support to the body and without it, we would just be a trillions cells without a shape or function. It is essentially the mortar between the bricks. The skin, bones, cartilage, tendons and ligaments are examples where the ECM is located in the body. The ECM is composed of material (fibrous elements) called elastin and collagen surrounded by a gelatinous substance (Hyaluronic Acid). HA’s roles in the ECM is to help the stretchy fibers in the body from overstretching and drying out by continually bathing them in this nutritious water base gelatinous fluid. It also serves as a wonderful medium through which nutrients and waste are transported to and from the cells of these structures. This fluid would not exist if it was not for the ability of the HA molecule to bind up to 1000 times its weight in water.

Hyaluronic Acid in the skin

The skin is the largest organ in the body comprising about 15% of the body weight. Roughly 50% of the Hyaluronic Acid in our body is found in the skin. HA and Collagen are vital to maintaining the skin’s layers and structure. It is the collagen that gives the skin its firmness but it is the HA that nourishes and hydrates the collagen. Imagine the collagen as the stretchy fibers that restore the skin back to shape when stretched. Collagen is like a rubber band but stretch that rubber band a million times, like what we do with our skin and without any moisture. Eventually that rubber band gets overstretched (saggy) and dried out and will most likely break. This is much the same way the collagen in our skin reacts leaving our skin in need of moisture. Now imagine that same rubber band stretched a million times while under water the whole time. Chances of that rubber band drying out and breaking are minimal. Consider the Hyaluronic Acid as the water that keeps the collagen moist and elastic. Collagen is continuously surrounded and nourished by the gelatinous HA substance. Young skin is smooth and highly elastic because it contains high concentrations of Hyaluronic Acid, which helps skin stay healthy. As we grow older, the body loses its ability to maintain this same concentration in the skin. With decreasing levels of HA in the skin, so goes the ability of the skin to hold water. The result, the skin becomes drier and loses its ability to maintain it’s hydration. Hyaluronic acid acts as a space filler by binding to water and thus keeping the skin wrinkle-free.

 

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SoQi Massage

SoQi Massage aka Power Nap aka Beauty Sleep

With over 38 years or research on 100,000 people the personal stories just keep coming in, the benefits of our SoQi Massage cannot be denied.

Imagine a Full Body Massage and workout equivalent to a 30 minute, non-impact aerobic exercise class (flat on your back), Lymphatic Drainage, Mini Spinal Alignment, Speeding up your metabolism where you’ll burn 900 calories an hour, Relieving your body of Aches Pains,  Benefiting from a Mini Power Nap, Deep Relaxation, along with music or subliminal messages from Ellen to lose weight or stop smoking or set weight, life or business goals, or pain relief, or build your self image, as you fade into alpha consciousnesses where you have no limits or boundaries.  “You can change your Life when you change your Mind”

AuraOur SoQi Massage combines two powerful, body transforming machines.  The patented technology of the Sun Ancon Chi Machine (anything else is a “toy”)  and our Far Infrared Hot Houses, benefit your body in many ways:

Sun Ancon Chi Machine:
*Full body massage
*Lymphatic massage
*Non-impact aerobic exercise
*Move and eliminate toxins
*Increase cirulation
*Relieve tired and sore muscles
*Nervousness, pain and insomnia
*Improve organ function
*Aid in Asthma and tracheal inflammation
*Weight issues
*Aura and energetic energy expanded

The benefits or Far InFraRed (FIR) are vast:
Oxygen Improvement *Elevates body temperature
*Expands blood capillaries
*Stimulates metabolism
*Promotes tissue regeneration
*Reduces cramping
*Creates “micro-friction” cell vibration and molecular resonance
*Aids is eliminating waste products from aging
*Removes heavy metals and toxic substances
*Adjusts the autonomic nerve function
*Reduces over-stimulation of sensory nerves

FIR HEAT IS FELT TO PRODUCE THERAPEUTIC EFFECTS IN THE FOLLOWING:

BRAIN
Short-term memory improved Accelerated repair in brain contusions
Cerebral hemorrhages – healing both speeds up and is significantly enhanced

COLLAGEN TISSUES
Ligaments Joint capsules Tendons
Fascia Synovium Increases range of motion
Scarred, thickened or contracted tissues
Increases extensibility of collagen tissues

BODY ACIDITY
Reduces acidity in the body (FIR causes fruit to ripen faster by reducing acidity)

NERVES
Neuresthenia Adjusts autonomic nerve function
Reduces over-stimulation of sensory nerves

CELLS
Attracts calcium ions to the cellular level
Promotes adhesion and osmosis of water molecules across the cellular membrane
Stimulates enzyme activity

JOINTS
Assists in reduction of swelling and inflammation by improving lymph flow
Decreases joint stiffness directly

PAIN RELIEF
Neuralgia Headache Pain during menstruation
May lead to increased endorphin production, which reduces pain

CONDITIONS AFFECTED BY CIRCULATION
Increases blood flow by promoting dilation of capillaries
Clogged capillary vessels Hypertension Arteriosclerosis
High blood pressure Low blood pressure Coronary artery disease
Arthritis Sciatica Backaches
Hemorrhoids Nervous tension Diabetes
Varicose veins Neuritis Bursitis
Rheumatism Strained muscles Fatigue
Stretch marks Menstrual cramps Upset stomach
Piles Poor peripheral circulation

CARDIOVASCULAR
Atherosclerosis (thickening of artery walls due to fatty deposits)
Septic shock (dangerous drop of blood pressure)
Due to the deep penetration over 1-1/2″ into the skin of the infrared rays generated by the FIR dome, there is a healing effect deep in the muscular tissues and the internal organs. The body responds to this deep healing affect as a hypothalamic-induced increase in both heart volume and rate. Research by NASA in the early 1980’s led to the conclusion that infrared stimulation of cardiovascular function would be the ideal way to maintain cardiovascular conditioning in American astronauts during long space flights. As the body works to cool itself, there is a substantial increase in heart rate, cardiac output and metabolic rate, and blood flow rises.

INFLAMMATORY INFILTRATES, EDEMA AND EXUDATES
Edema of the joints Inflammation of joints Tendinitis
Sprain Joint stiffness Peripheral Occlusive Disease
Gout
Speeds up healing – treatment with infrared has been so successful that hospital stays were reported to have been reduced by 25%.

CANCER
Cancer therapy Cancer of the tongue
Radiation sickness – relieves signs & symptoms
Cancer pain – relieved in later stages of cancer
FIR heat can penetrate through the body and kill cancerous cells

Cancerous cells cannot exist if blood circulation is smooth. Good circulation in the capillaries leaves no room for a cancerous cell to settle down. (A cancerous cell has to settle down so it can proliferate.) FIR helps capillaries to expand, improving circulation. The cancer cell also has a weakness: heat above 42 deg C can kill it. FIR heat can penetrate through the body and kill cancerous cells. FIR treatment raises body temperature. FIR therapy can alleviate pain and prolong life when conventional cancer treatment fails. Surgery, radiotherapy and chemotherapy are considered detrimental to health – they are invasive treatments. FIR therapy and immuno-therapy are regarded as non-invasive. FIR is extremely beneficial.

DENTISTRY
Dr. John Tate, DDS, says, “I have used the FIR dome with over fifty high risk surgical cases without complication or dry sockets on 92% of the patients. The dome is placed over the patient in my office a half hour before surgery and then a half hour after surgery to promote an immune response. The patient then takes the dome home and applies the technology at home for two hours a day for the next three days. They get what we call complete healing. The macrophages produce collagen necessary to stimulate the fibroblasts, and the tissue of the fibroblasts then will stimulate the osteoblast, which is bone. That is where the bone forms – and it starts in the first three days – but it takes about six months for complete healing. The two main cells we need in dentistry and in surgery around the bone area are the macrophages and the neutrophils.” (which are activated by far infrared heat).

“The macrophage is called the “pac man” of the immune system. The macrophage is a cell that engulfs and digests microorganisms. Everything starts with the macrophage – “macro” meaning big and “phage” meaning eater. So we have a big eater here. The tentacle on the macrophage grabs the staphylococci and a bacillus rod, and that macrophage extends a pseudo paw to get the bacteria that is now invading our blood!”

“I elected to use the FIR dome for these reasons:
1. Safety. The FIR produces a wave length that is identical to the body’s own wave length by body heat, and that is at the 8-to-10-micron level, so it is safe.
2. Penetration. FIR penetrates 1-1/2″ so this is an advantage to the dental surgeon who deals with bone as well as soft tissue.
3. Area covered. The unique ceramic construction of the FIR dome covers a large area of the body, with a large coverage in a short period of time. Since there is a 160-degree angle, the penetration and the intensity of the dome produces a strong effect.
4. One hour’s use of the FIR dome for five days would produce a large body production of nitric oxide gas. It will also increase circulation, reduce pain and swelling and promote faster healing. That has been my observation with about 50 patients now. They tell me, ‘Doc, I don’t need any more antibiotics; I am healing; I feel good; I don’t have any swelling.’”

IMMUNE SYSTEM
Pelvic infection Post-surgical infection
Toe-and-finger-nail fungus
Scleraderma (an autoimmune disease where collagen builds up and healing cannot take place because the circulation can’t get to the area due to the buildup of the collagen)
Infrared energy appears capable of potentiating functions of white blood cells. More white blood cells means greater immune function and resistance to disease and viruses.

There is an immune response facilitated by the photons of the FIR technology that turns on the enzyme system, particularly the nitric oxide synthase enzyme. It is well established medically that this is the mechanism involved in the FIR technology.

PROBLEMS THAT OFTEN ACCOMPANY AGING
Menopause Cold hands & feet High blood pressure
Rheumatoid arthritis Radiation sickness Sequelae of strokes
Leg ulcers Rheumatism Insomnia
Benign prostatic hypertrophy Pain which affects ability to sleep
Pain from a metal joint implant Speeds healing of joint implants
Compression fracture pain

DISEASES OF ORGANS
Duodenal ulcers Hepatitis Gastritis
Cirrhosis of liver Hemorrhoids Asthma
Bronchitis Crohn’s Disease Post-surgical adhesions
Cystitis Heartburn Nephritis
Gastric and duodenal ulcers Stomach ache Gastroenteric
Reduces density of uric acid Cholecystitis

EAR, NOSE, THROAT CONDITIONS
Sore throats Earache Nosebleeds
Tinea
Chronic middle-ear inflammation & infection
Tinitus – chronic, severe case cleared with 10 FIR treatments

RESPIRATORY
Chest colds Bronchitis Pneumonia

SKIN CONDITIONS
Clogged pores. Poor skin tone. Open wounds
Laceration Body odor Loosens dead outer skin
Eczema Psoriasis Aging skin
Chapping Chillblains Frostbite
Rashes Removes roughness Improves skin tone
Nettle rash Neurodermatitis
Leg & Decubitus ulcers improved when previously resistant to other care
Dandruff – due to increased blood flow through the scalp
Burns – Scars and pain from burns and wounds are decreased in severity and extent. FIR therapy is used routinely in burn units throughout Asia.
Keloids – significantly softened and in some cases completely gone
Acne – FIR may open pores that have not been functioning in years
Sunburn – FIR radiations are the only antidote to excessive ultraviolet radiation, according to Clayton’s Electrotherapy, Ninth Ed.

MUSCULOSKELETAL
Arthritis Accel-decel injury sequelae Brain contusion
Lumbago Relieves muscle spasms TMJ arthritis
Cramping Whiplash Lumbar strain
Muscle tension Spinal cord shock Post-exercise muscle pain
Bursitis Muscle spasms Knee injuries
Paralysis Sciatica Neuralgia
Abnormal nerve functions
Back, shoulder, neck and muscle pain
Facial paralysis (Bell’s Palsy)
Reduces muscle spasms as muscle fibers are heated
Great for warming up before exercise

SOFT TISSUE
Soft tissue injuries – promotes relief in chronic cases Accelerated healing in newer injuries
Auto accident-related soft tissue injury Cellulite
Aids in regeneration of tissue
Reduces soreness through direct action on nerve endings in tissues and on periphery

WEIGHT LOSS
Direct excretion of fat. Burns calories Increases metabolism
Weight loss can come through the energy use needed to produce sweating
Cellulite (a gel-like substance made up of fat, water and wastes, which are trapped in pockets below the skin) A FIR dome will assist this condition, as profuse sweating helps clear it from the body. FIR heat can be significantly more effective than other heat methods, due to the heat penetration being twice the depth into cellulite.

As a FIR dome is an unsurpassed expeller of toxins, it is also a great way to get rid of any fat our bodies are using to dilute toxins we are storing. Two of the highest caloric output forms of exercise are rowing and marathon running. Peak output in these sports burns about 600 calories in 30 minutes. Infrared use may better this effect by burning some 900 calories in a 30-minute session. Thus Infrared might stimulate the consumption of energy equal to that expended in a 6.9 mile run during only a single session. The cleansing and purifying benefits attributed to the traditional sweat lodges are now available for daily purification without the time-consuming set-up process that a sweat lodge requires.

EXERCISE AND CONDITIONING EFFECT
An infrared system can play a pivotal role in both weight control and cardiovascular conditioning. The Infrared dome makes it possible for people in wheelchairs, or those who are otherwise unable to exert themselves or who won’t follow through on an exercise and conditioning program to achieve a cardiovascular training effect. This also allows for more variety in any ongoing training program. “Regular use may be as effective, as a means of cardiovascular conditioning and burning of calories, as regular exercise.”

For athletes, the FIR dome helps the oxygen-debt to be repaid more quickly. The FIR dome is great for warming up before stretching or starting any vigorous activity. Allow the FIR rays to pour right through your clothing until you just begin to break a sweat. Now you are pre-warmed for stretching, running, skiing in cold weather. This should help to prevent injuries.

CASE STUDY
Rheumatoid arthritis in a 14-year-old Swedish girl who couldn’t walk comfortably downstairs due to knee pain since she had been eight years old. Her rheumatologists told her mother that she would be in a wheelchair within two years. However, after three infrared treatments she began to become more agile and subsequently took up folk dancing, without the aid of the conventional approach in her recovery.

Warming Up to Far Infrared

References
Infrared’s Effect on Dentistry and the Immune System, John L. Tate, DDS.
Far-Infrared – Technologies That Harness the Sun, Valerie H. Free, Complimentary Healing.
Warming up to Far-Infrared, D.J. Fletcher, Alternative Medicine, Jan. 2001.
Infrared Thermal System, Dr. Aaron M.Flickstein, Thermal Life Infrared.
The Healing Rays of Far-Infrared, Hsin Ten Enterprises.
Augmentation of Wound Healing Using Monochromatic Infrared Energy, Lon R.Horwitz, DPM, CWS; Thomas J. Burke, PhD; Dale Carnegie, DPM, Advances in Wound Care, Jan./Feb.1999.
Medical Report, HotHouse FIR Health Builder.
Clayton’s Electrotherapy, Ninth Ed.
Therapeutic Heat and Cold, 4th Ed, ED, Justus F. Lehmann, M.D.
The Science of Far Infrared Therapies, Toshiko Yamazaki, M.D.

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